Salvinorin A:: A novel and highly selective κ-opioid receptor agonist

被引：49

作者：

Feng, Y ^{[1
]}

Roth, BL ^{[1
]}

机构：

[1] Case Western Reserve Univ, Sch Med, Dept Biochem, Cleveland, OH 44106 USA

来源：

LIFE SCIENCES | 2004年 / 75卷 / 22期

关键词：

kappa-opioid receptors; kappa-opioid agonists; salvinorin A;

D O I：

10.1016/j.lfs.2004.07.008

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

K-opioid receptors (KORs) represent the principal site of action of dynorphin and related neuropeptides. Recently, Salvinorin A-a naturally occurring neoclerodane diterpene hallucinogen was identified to be a highly selective KOR agonist. In this brief review we summarize the known chemistry, pharmacology and biology of salvinorin A. Because salvinorin A profoundly alters human consciousness and perception, a study of how salvinorin A exerts its actions on KORs may yield novel insights into the molecular and cellular basis of uniquely human higher cortical functions. (C) 2004 Elsevier Inc. All rights reserved.

引用

页码：2615 / 2619

页数：5

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