The involvement of plasmacytoid cells in HIV infection and pathogenesis

被引：18

作者：

Aiello, Alessandra ^{[1
]}

Giannessi, Flavia ^{[1
]}

Percario, Zulema A. ^{[1
]}

Affabris, Elisabetta ^{[1
]}

机构：

[1] Univ Roma Tre, Dept Sci, Viale Guglielmo Marconi, Rome, Italy

来源：

CYTOKINE & GROWTH FACTOR REVIEWS | 2018年 / 40卷

关键词：

Plasmacytoid cells; Immune activation; Type I interferon; HIV infection; IMMUNODEFICIENCY-VIRUS TYPE-1; ALPHA-PRODUCING CELLS; MYELOID DENDRITIC CELLS; REGULATORY T-CELLS; INHIBITS TLR9-MEDIATED ACTIVATION; INTERFERON-PRODUCING CELLS; TRANSCRIPTION FACTOR E2-2; COLONY-STIMULATING FACTOR; INFLAMED LYMPH-NODES; IFN-PRODUCING CELLS;

D O I：

10.1016/j.cytogfr.2018.03.009

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Plasmacytoid dendritic cells (pDCs) are a unique dendritic cell subset that are specialized in type I interferon (IFN) production. pDCs are key players in the antiviral immune response and serve as bridge between innate and adaptive immunity. Although pDCs do not represent the main reservoir of the Human Immunodeficiency Virus (HIV), they are a crucial subset in HIV infection as they influence viral transmission, target cell infection and antigen presentation. pDCs act as inflammatory and immunosuppressive cells, thus contributing to HIV disease progression. This review provides a state of art analysis of the interactions between HIV and pDCs and their potential roles in HIV transmission, chronic immune activation and immunosuppression. A thorough understanding of the roles of pDCs in HIV infection will help to improve therapeutic strategies to fight HIV infection, and will further increase our knowledge on this important immune cell subset.

引用

页码：77 / 89

页数：13

共 200 条

[1]

Role of the Nlrp3 inflammasome in microbial infection [J].