General asymmetric hydrogenation of hetero-aromatic ketones

被引：163

作者：

Ohkuma, T

Koizumi, M

Yoshida, M

Noyori, R ^{[1
]}

机构：

[1] Nagoya Univ, Dept Chem, Chikusa Ku, Nagoya, Aichi 4648602, Japan

[2] Nagoya Univ, Res Ctr Mat Sci, Chikusa Ku, Nagoya, Aichi 4648602, Japan

来源：

ORGANIC LETTERS | 2000年 / 2卷 / 12期

关键词：

D O I：

10.1021/ol0000814

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] trans-RuCL2[(R)-xylbinap][(R)-daipen] or the S,S complex acts as an efficient catalyst for asymmetric hydrogenation of hetero-aromatic ketones. The hydrogenation proceeds with a substrate-to-catalyst molar ratio of 1000-40000 to give chiral alcohols in high ee and high yield. The enantioselectivity appears to be little affected by the properties of the hetero-aromatic ring. This method allows for asymmetric synthesis of duloxetine, an inhibitor of serotonin and norepinephrine uptake carriers.

引用

页码：1749 / 1751

页数：3

共 43 条

[1] Enzymatic resolution of (R)- and (S)-2-(1-hydroxyalkyl)thiazoles, synthetic equivalents of (R)- and (S)-2-hydroxy aldehydes [J].