Immunologic response to combination nucleoside analogue plus protease inhibitor therapy in stable antiretroviral therapy-experienced human immunodeficiency virus-infected children

被引:44
作者
Borkowsky, W
Stanley, K
Douglas, SD
Lee, S
Wiznia, A
Pelton, S
Yogev, R
McIntosh, K
Nachman, S
机构
[1] NYU, Sch Med, Div Infect Dis, New York, NY 10016 USA
[2] SUNY Stony Brook, Dept Pediat, Stony Brook, NY 11794 USA
[3] Jacobi Med Ctr, Pediat HIV Serv, Bronx, NY USA
[4] Harvard Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02115 USA
[5] Boston Univ, Sch Med, Boston, MA 02118 USA
[6] Childrens Hosp, Div Infect Dis, Boston, MA 02118 USA
[7] Childrens Hosp Philadelphia, Div Immunol & Infect Dis, Philadelphia, PA 19104 USA
[8] Northwestern Univ, Sch Med, Sect Pediat & Maternal HIV Infect, Chicago, IL USA
基金
美国国家卫生研究院;
关键词
D O I
10.1086/315672
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The response of 40 immunologic parameters was studied for 147 clinically stable, protease inhibitor-naive, human immunodeficiency virus (HIV)-infected children aged 2-17 years when antiretroviral therapy was changed to either a dual nucleoside analogue regimen or a protease inhibitor-containing regimen. Immunologic response to therapy, as measured by lymphocyte subsets, 3-color flow cytometric measures, and lymphoproliferative assays, were investigated for changes in weeks 44 and 48, The most significant changes after baseline that were associated with the administration of a protease inhibitor-containing regimen were seen for percentages of CD8(+)/CD38(+)/HLA-DR+, CD8(+)/CD95(+)/CD28(-), and CD8, The percentages of CD8(+)/CD38(+)/HLA-DR+ and CD8(+)/CD95(+)/CD28(-) decreased from baseline medians of 33% and 46% to medians of 18% and 30% at week 44 (P < .0001 for both). Median CD4 cell count increased 168 cells/mu L (from 694 cells/mu L to 862 cells/mu L; P = .02) by week 48 in this clinically stable population. Changes in lymphoproliferative responses to HIV antigens and recall antigens did not increase over time and between groups.
引用
收藏
页码:96 / 103
页数:8
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