Agelastatins C and D, new pentacyclic bromopyrroles from the sponge Cymbastela sp., and potent arthropod toxicity of (-)-agelastatin A

被引：84

作者：

Hong, TW

Jímenez, DR

Molinski, TF ^{[1
]}

机构：

[1] Univ Calif Davis, Dept Chem, Davis, CA 95616 USA

[2] Novo Nordisk Entotech Inc, Davis, CA 95616 USA

来源：

JOURNAL OF NATURAL PRODUCTS | 1998年 / 61卷 / 01期

关键词：

D O I：

10.1021/np9703813

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two new agelastatins, C (3) and D (4), along with the known compound (-)-agelastatin A ii), were isolated from the Indian Ocean sponge Cymbastela sp. The structures were determined by analysis of spectroscopic data and chemical correlation of 4 with a common derivative 5, also prepared from 1. Agelastatin A (1) exhibited potent activity against brine shrimp (LC50 1.7 ppm) in addition to insecticidal activity against larvae of beet army worm, Spodoptera exigua, and corn rootworm, Diabrotica undecimpunctata.

引用

页码：158 / 161

页数：4