Circadian regulation of cortisol after hippocampal damage in humans

被引:165
作者
Buchanan, TW
Kern, S
Allen, JS
Tranel, D
Kirschbaum, C
机构
[1] Univ Iowa, Dept Neurol, Iowa City, IA 52242 USA
[2] Tech Univ Dresden, Dept Psychol, Dresden, Germany
关键词
cortisol; hippocampus; HPA axis; amygdala; medial temporal lobe;
D O I
10.1016/j.biopsych.2004.08.014
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Background There is substantial evidence that the hippocampus (HC) regulates the activity of the hypothalamic-pituitary-adrenocortical (HPA) axis. Damage to the HC in animals produces a transient alteration in diurnal and stress-related HPA activity. This study was designed to examine the effects of HC damage on basal cortisol secretion in humans. Methods: Salivary cortisol was measured in 22 patients with HC damage (12 with bilateral damage and 10 with unilateral damage), 7 brain-damaged comparison participants, 10 healthy, age-matched comparison participants, and 6 of the patients' caregivers. Salivary cortisol samples were taken immediately after awakening, 30 min after awakening, at 8:00 AM, 11:00 AM, 3:00 Pm, 600 Pm, and at bedtime on a single day. Brain-injured patients underwent a structural magnetic resonance imaging scan to examine quantitative volumes of the HC. Results: Both bilateral and unilateral HC damage abolished the cortisol response to awakening documented in the comparison groups. Caregivers of bilateral HC patients showed a reduced response to awakening. The remainder of the circadian pattern was not affected in the HC patients,: all groups showed a significant diurnal variation. There was no association between HC volume and cortisol secretion. Conclusions: Hippocampal damage in humans abolishes the cortisol response to awakening, whereas the remainder of the diurnal cycle is unaffected in these patients. These data suggest a unique role of the HC in the control of basal cortisol secretion.
引用
收藏
页码:651 / 656
页数:6
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