Enzymes and abzymes relationships

被引：3

作者：

Avalle, B ^{[1
]}

Friboulet, A ^{[1
]}

Thomas, D ^{[1
]}

机构：

[1] Univ Technol Compiegne, CNRS, UPRESA 6022, F-60205 Compiegne, France

来源：

JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC | 2000年 / 10卷 / 1-3期

关键词：

catalytic antibodies; abzymes; anti-idiotypic antibodies; metabolism;

D O I：

10.1016/S1381-1177(00)00106-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Antibodies and enzymes are proteins that bind macromolecules and small natural and synthetic ligands with high specificity and high affinity. While enzymes have been perfecting their skills during evolution to reach very efficient structures for catalysis, antibody-binding sites evolve toward efficient structures for binding in a few weeks. The generation of antibodies bearing catalytic activities (abzymes) brings new insights in the understanding on the evolution of the catalytic function, and also on functions that the immune system could play in metabolism. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：39 / 45

页数：7

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