How are specialized (low-fidelity) eukaryotic polymerases selected and switched with high-fidelity polymerases during translesion DNA synthesis?

被引：18

作者：

Fischhaber, PL ^{[1
]}

Friedberg, EC ^{[1
]}

机构：

[1] Univ Texas, SW Med Ctr Dallas, Lab Mol Pathol, Dept Pathol, Dallas, TX 75390 USA

来源：

DNA REPAIR | 2005年 / 4卷 / 02期

关键词：

TLS; low-fidelity; Y-family; eta; kappa; iota; zeta; SUMO; ubiquitin; PCNA; polymerase switching; xeroderma pigmentosum; XPV; posttranslational; modification;

D O I：

10.1016/j.dnarep.2004.08.011

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Specialized DNA polymerases are required in both prokaryotic and eukaryotic cells for bypassing sites of template DNA damage that arrest high-fidelity DNA replication. Recent studies in the literature provide hints of the complexity of DNA switching between polymerases for translesion DNA synthesis (TLS) and those for normal DNA replication. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：279 / 283

页数：5

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