PKC-interacting proteins: from function to pharmacology

被引:112
作者
Poole, AAW [1 ]
Pwa, G [1 ]
Hers, M [1 ]
Crosby, D [1 ]
Jones, ML [1 ]
机构
[1] Sch Med Sci, Dept Pharmacol, Bristol BS8 1TD, Avon, England
基金
英国惠康基金;
关键词
D O I
10.1016/j.tips.2004.08.006
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Protein kinase C (PKC) is a ubiquitously expressed family of kinases that have key roles in regulating multiple cellular activities. The activity of this family is controlled tightly by several molecular mechanisms, including interaction with binding-partner proteins. These PKC-interacting proteins (C-KIPs) confer specificity for individual PKC isoforms by regulating the activity and cellular localization of PKC isoforms and, subsequently, the ability of these isoforms to specifically regulate cellular functional events. Although many C-KIPs have been identified by genome and proteome-mining approaches, it is important to address the specificity and function of the interactions in greater detail because they might form novel drug targets. In this article, we review recent work on C-KIPs and the implications for pharmacological and therapeutic development.
引用
收藏
页码:528 / 535
页数:8
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