Molecular communication between androgen receptor and general transcription machinery

被引:67
作者
Lee, DK
Chang, C
机构
[1] George Whipple Lab Canc Res, Dept Pathol, Rochester, NY 14642 USA
[2] George Whipple Lab Canc Res, Dept Urol, Rochester, NY 14642 USA
[3] George Whipple Lab Canc Res, Ctr Canc, Rochester, NY 14642 USA
关键词
androgen target gene; AR; PSA; RNA polymerase II; transcription; transcriptional elongation; TFIIF; TFIIH;
D O I
10.1016/S0960-0760(03)00005-0
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The androgen-androgen receptor (AR) signaling pathway plays a key role in proper development and function of male reproductive organs. Like other transcriptional regulators, AR may communicate with the general transcription machinery on the core promoter to exert its function as a transcriptional modulator. The molecular communication between AR and the general transcription machinery may be achieved either by the direct protein-protein interaction between AR and the general transcription machinery or by the indirect interaction mediated by coregulators. Analyses of AR-mediated transcription suggest that the orchestrated interaction of AR with the transcription factors 1117 (TFIIF) and IIH (TFIIH), and positive transcription elongation factor b (P-TEFb), may increase efficiency of transcriptional elongation from the androgen target genes, such as prostate specific antigen (PSA). Based on studies so far, AR may regulate transcription not by enhanced assembly of preinitiation transcription complex but by regulating promoter clearance and elongation stage of transcription. (C) 2003 Elsevier Science Ltd. All fights reserved.
引用
收藏
页码:41 / 49
页数:9
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