Leptin and the regulation of body weight

被引：164

作者：

Considine, RV ^{[1
]}

Caro, JF ^{[1
]}

机构：

[1] Thomas Jefferson Univ, Jefferson Med Coll, Dept Med, Div Endocrinol & Metab, Philadelphia, PA 19107 USA

来源：

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY | 1997年 / 29卷 / 11期

关键词：

ob gene; leptin; leptin receptor; obesity;

D O I：

10.1016/S1357-2725(97)00050-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Leptin has received considerable attention as a newly recognized metabolic hormone and for its potential for therapeutic use in the treatment of human obesity. Furthermore, defects in the leptin signal pathway that result in obesity in animal models have raised the possibility of a similar etiology for obesity in humans. This review will summarize the current findings on leptin in both humans and rodents. These findings mill be discussed with respect to our view of the physiology and potential for pathophysiology in leptin-mediated regulation of body weight and composition. (C) 1997 Published by Elsevier Science Ltd. All rights reserved.

引用

页码：1255 / 1272

页数：18

共 117 条

[51] Leptin is related to body fat content in male distance runners
Hickey, MS
Considine, RV
Israel, RG
Mahar, TL
McCammon, MR
Tyndall, GL
Houmard, JA
Caro, JF
[J]. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 1996, 271 (05): : E938 - E940
[52] Development of radioimmunoassay for human leptin
Hosoda, K
Masuzaki, H
Ogawa, Y
Miyawaki, T
Hiraoka, J
Hanaoka, I
Yasuno, A
Nomura, T
Fujisawa, Y
Yoshimasa, Y
Nishi, S
Yamori, Y
Nakao, K
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1996, 221 (02) : 234 - 239
[53] Long-term and rapid regulation of ob mRNA levels in adipose tissue from normal (Sprague Dawley rats) and obese (db/db mice, fa/fa rats) rodents
Igel, M
Kainulainen, H
Brauers, A
Becker, W
Herberg, L
Joost, HG
[J]. DIABETOLOGIA, 1996, 39 (07) : 758 - 765
[54] STRUCTURAL ORGANIZATION AND CHROMOSOMAL ASSIGNMENT OF THE HUMAN OBESE GENE
ISSE, N
OGAWA, Y
TAMURA, N
MASUZAKI, H
MORI, K
OKAZAKI, T
SATOH, N
SHIGEMOTO, M
YOSHIMASA, Y
NISHI, S
HOSODA, K
INAZAWA, J
NAKAO, K
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (46) : 27728 - 27733
[55] Antidiabetic thiazolidinediones inhibit leptin (ob) gene expression in 3T3-L1 adipocytes
Kallen, CB
Lazar, MA
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (12) : 5793 - 5796
[56] THE ROLE OF DEPOT FAT IN THE HYPOTHALAMIC CONTROL OF FOOD INTAKE IN THE RAT
KENNEDY, GC
[J]. PROCEEDINGS OF THE ROYAL SOCIETY SERIES B-BIOLOGICAL SCIENCES, 1953, 140 (901): : 578 - 592
[57] Adipose tissue leptin production and plasma leptin kinetics in humans
Klein, S
Coppack, SW
MohamedAli, V
Landt, M
[J]. DIABETES, 1996, 45 (07) : 984 - 987
[58] Responses of leptin to short-term fasting and refeeding in humans - A link with ketogenesis but not ketones themselves
Kolaczynski, JW
Considine, RV
Ohannesian, J
Marco, C
Opentanova, I
Nyce, MR
Myint, M
Caro, JF
[J]. DIABETES, 1996, 45 (11) : 1511 - 1515
[59] Acute and chronic effect of insulin on leptin production in humans - Studies in vivo and in vitro
Kolaczynski, JW
Nyce, MR
Considine, RV
Boden, G
Nolan, JJ
Henry, R
Mudaliar, SR
Olefsky, J
Caro, JF
[J]. DIABETES, 1996, 45 (05) : 699 - 701
[60] Response of leptin to short-term and prolonged overfeeding in humans
Kolaczynski, JW
Ohannesian, JP
Considine, RV
Marco, CC
Caro, JF
[J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1996, 81 (11) : 4162 - 4165

← 1 2 3 4 5 6 7 8 9 10 →