The effects of particulate polyethylene at a weight-bearing bone-implant interface - A study in rats

被引：58

作者：

Allen, M ^{[1
]}

Brett, F ^{[1
]}

Millett, P ^{[1
]}

Rushton, N ^{[1
]}

机构：

[1] ADDENBROOKES HOSP,DEPT HISTOPATHOL,CAMBRIDGE CB2 2QQ,ENGLAND

来源：

JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME | 1996年 / 78B卷 / 01期

关键词：

D O I：

10.1302/0301-620X.78B1.0780032

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

In ten male rats we inserted ceramic 'drawing-pin' implants in weight-bearing positions within the right proximal tibia. Two animals were killed 6 weeks after surgery and two more 14 weeks after surgery. The remaining six received intra-articular injections of either high-density polyethylene (4 rats) or saline (2 rats) at 8, 10 and 12 weeks after surgery, These animals were killed two weeks after the last injection, Histological examination of the bone-implant interface in the control animals showed appositional bone growth around the implant at both 6 and 14 weeks, Polyethylene, but not saline, caused a chronic inflammatory response with numerous foreign-body giant cells in periprosthetic tissues, Our model of a stable, weight-bearing bone-implant interface provides a simple and reliable system in which to study in vivo the effects of particulate materials used in orthopaedic surgery.

引用

页码：32 / 37

页数：6

共 28 条

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