Anti-inflammatory properties of HDL

被引：35

作者：

Ansell, BJ ^{[1
]}

Navab, M ^{[1
]}

Watson, KE ^{[1
]}

Fonarow, GC ^{[1
]}

Fogelman, AM ^{[1
]}

机构：

[1] Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Div Cardiol,Atherosclerosis Res Unit, Los Angeles, CA 90095 USA

来源：

REVIEWS IN ENDOCRINE & METABOLIC DISORDERS | 2004年 / 5卷 / 04期

关键词：

HDL; LDL; lipid oxidation; inflammation;

D O I：

10.1023/B:REMD.0000045107.71895.b2

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The formation of oxidized phospholipids within LDL activates the innate immune system. These oxidized phospholipids are generated from arachidonic acid via the lipoxygenase and myeloperoxidase pathways. Phospholipid oxidation may also affect reverse cholesterol transport. The HDL inflammatory index and measurements of the levels of lipid oxidation products in lipoproteins including products of the myeloperoxidase pathway may predict susceptibility to atherogenesis. The ability of ApoA-I and apoA-I mimetic peptides to reduce levels of oxidized lipids and also improve reverse cholesterol transport may have therapeutic potential.

引用

页码：351 / 358

页数：8

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