Efficient synthesis and dehydration reaction of trichloromethylated 2-(3-phenyl-5-hydroxy-4,5-dihydro-1 H-pyrazol-1-yl)-4-aryl-5-alkylthiazoles

被引：10

作者：

Bonacorso, HG ^{[1
]}

Muniz, MN ^{[1
]}

Wastowski, AD ^{[1
]}

Zanatta, N ^{[1
]}

Martins, MAP ^{[1
]}

机构：

[1] Univ Fed Santa Maria, Dept Quim, BR-97105900 Santa Maria, RS, Brazil

来源：

HETEROATOM CHEMISTRY | 2003年 / 14卷 / 02期

关键词：

D O I：

10.1002/hc.10113

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A convenient method for the synthesis of a novel series of 11, specifically substituted, noncondensed 5,5-bicycles 2-[3-phenyl-5-hydroxy-5trichloromethyl- 4,5-dihydro-1H-pyrazol-1-yl]-4-aryl-5-alkylthiazoles (3a-k; 65-94% yield) from the reactions of 3-phenyl-5-hydroxy-5-trichloromethyl-4,5-dihydro-1H-1-pyrazolethiocarboxyamide (1) with substituted 2-bromo-4'-acetophenones (2a-f) and 2-bromo-4'-propiophenones (2g-k) is reported. Dehydration of compounds 3a-k with a mixture of concentrated sulfuric acid/chloroform furnished the corresponding 2-[3-phenyl-5-trichloromethyl-1H-pyrazol-1-yl]-4-aryl-5-alkylthiazoles (4a-k) in good yields (61-93%). (C) 2003 Wiley Periodicals, Inc.

引用

页码：132 / 137

页数：6

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