Treatment of pure red cell aplasia and autoimmune haemolytic anaemia in chronic lymphocytic leukaemia with Campath-1H

被引：31

作者：

Rodon, P ^{[1
]}

Breton, P ^{[1
]}

Courouble, G ^{[1
]}

机构：

[1] Ctr Hosp Gen, Dept Internal Med & Haematol, F-41016 Blois, France

来源：

EUROPEAN JOURNAL OF HAEMATOLOGY | 2003年 / 70卷 / 05期

关键词：

chronic lymphocytic leukaemia; autoimmune haemolytic anaemia; pure red cell aplasia; Campath-1H;

D O I：

10.1034/j.1600-0609.2003.00055.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A patient with chronic lymphocytic leukaemia (CLL) progressive on fludarabine therapy and life-threatening anaemia related to immune haemolysis and pure red cell aplasia was treated with Campath-1H. The patient had sustained complete remission of both CLL and anaemia, but died of recurrent sepsis and cachexia 10 months after completion of the treatment. Campath-1H (alemtuzumab), a humanised anti-CD52 monoclonal antibody, is a potent therapeutic agent against advanced CLL and immune cytopenias. It could be indicated in the treatment of severe immune complications of CLL unresponsive to corticosteroids. Prolonged immunosuppression is a serious side-effect leading to severe infectious complication.

引用

页码：319 / 321

页数：3

共 16 条

[1]

Cesana C, 1996, LEUKEMIA, V10, P1400

[2] Autoimmune haemolysis in patients with B-CLL treated with chlorodeoxyadenosine (CDA) [J].

Chasty, RC ;

Myint, H ;

Oscier, DG ;

Orchard, JA ;

Bussutil, DP ;

Hamon, MD ;

Prentice, AG ;

Copplestone, JA .

LEUKEMIA & LYMPHOMA, 1998, 29 (3-4) :391-398

[3] PURE RED-CELL APLASIA IN PATIENTS WITH CHRONIC LYMPHOCYTIC-LEUKEMIA [J].

CHIKKAPPA, G ;

ZARRABI, MH ;

TSAN, MF .

MEDICINE, 1986, 65 (05) :339-351

[4]

Diehl LF, 1998, SEMIN ONCOL, V25, P80

[5] Pure red cell aplasia [J].

Fisch, P ;

Handgretinger, R ;

Schaefer, HE .

BRITISH JOURNAL OF HAEMATOLOGY, 2000, 111 (04) :1010-1022

[6] Successful treatment of pure red cell aplasia with rituximab in patients with chronic lymphocytic leukemia [J].

Ghazal, H .

BLOOD, 2002, 99 (03) :1092-1094

[7] Epstein-Barr virus associated diffuse large B-cell lymphoma complicated by autoimmune hemolytic anemia and pure red cell aplasia [J].

Katayama, H ;

Takeuchi, M ;

Yoshino, T ;

Munemasa, M ;

Tada, A ;

Soda, R ;

Takahashi, K .

LEUKEMIA & LYMPHOMA, 2001, 42 (03) :539-542

[8] Therapeutic role of alemtuzumab (Campath-1H) in patients who have failed fludarabine: results of a large international study [J].

Keating, MJ ;

Flinn, I ;

Jain, V ;

Binet, JL ;

Hillmen, P ;

Byrd, J ;

Albitar, M ;

Brettman, L ;

Santabarbara, P ;

Wacker, B ;

Rai, KR .

BLOOD, 2002, 99 (10) :3554-3561

[9] PURE RED-CELL APLASIA WITH FLUDARABINE FOR CHRONIC LYMPHOCYTIC-LEUKEMIA [J].

LEPORRIER, M ;

REMAN, O ;

TROUSSARD, X .

LANCET, 1993, 342 (8870) :555-555

[10] Autoimmune hemolytic anemia in chronic lymphocytic leukemia: clinical, therapeutic, and prognostic features [J].

Mauro, FR ;

Foa, R ;

Cerretti, R ;

Giannarelli, D ;

Coluzzi, S ;

Mandelli, F ;

Girelli, G .

BLOOD, 2000, 95 (09) :2786-2792

← 1 2 →