Targeting polyamine metabolism and function in cancer and other hyperproliferative diseases

被引：611

作者：

Casero, Robert A., Jr. ^{[1
]}

Marton, Laurence J.

机构：

[1] Johns Hopkins Univ, Sch Med, Sidney Kimmel Comprehens Canc Ctr, Baltimore, MD 21231 USA

[2] Cellgate, Redwood City, CA 94065 USA

来源：

NATURE REVIEWS DRUG DISCOVERY | 2007年 / 6卷 / 05期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nrd2243

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The polyamines spermidine and spermine and their diamine precursor putrescine are naturally occurring, polycationic alkylamines that are essential for eukaryotic cell growth. The requirement for and the metabolism of polyamines are frequently dysregulated in cancer and other hyperproliferative diseases, thus making polyamine function and metabolism attractive targets for therapeutic intervention. Recent advances in our understanding of polyamine function, metabolic regulation, and differences between normal cells and tumour cells with respect to polyamine biology, have reinforced the interest in this target-rich pathway for drug development.

引用

页码：373 / 390

页数：18

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