Vaccine research efforts for filoviruses

被引：47

作者：

Hart, MK ^{[1
]}

机构：

[1] USA, Med Res Inst Infect Dis, Div Virol, Frederick, MD 21702 USA

来源：

INTERNATIONAL JOURNAL FOR PARASITOLOGY | 2003年 / 33卷 / 5-6期

关键词：

Ebola virus; Marburg virus; filovirus; vaccine; immunity;

D O I：

10.1016/S0020-7519(03)00064-X

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Ebola and Marburg viruses belong to the family Filoviridae, and cause acute, frequently fatal, haemorrhagic fever in humans and nonhuman primates. No vaccines are available for human use. This review describes the status of research efforts to develop vaccines for these viruses and to identify the immune mechanisms of protection. The vaccine approaches discussed include DNA-based vaccines, and subunit vaccines vectored by adenovirus, alphavirus replicons, and vaccinia virus. (C) 2003 Australian Society for Parasitology Inc. Published by Elsevier Science Ltd. All rights reserved.

引用

页码：583 / 595

页数：13

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