Rapid assembly and synthetic applications of a supported poly-α-amino acid containing phosphine groups

被引:9
作者
Edwards, CW
Shipton, MR
Wills, M [1 ]
机构
[1] Univ Warwick, Dept Chem, Coventry CV4 7AL, W Midlands, England
[2] SmithKline Beecham Pharmaceut, Harlow CM19 5AW, Essex, England
关键词
D O I
10.1016/S0040-4039(00)01512-4
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A simple method for the rapid multiplication of the number of available amine sites on a polymer bead, using lysine N-carboxyanhydride, is described. The product may be functionalised with a phosphine and employed in a catalytic reaction. (C) 2000 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:8615 / 8619
页数:5
相关论文
共 22 条
  • [1] Improved procedure for Julia-Colonna asymmetric epoxidation of α,β-unsaturated ketones:: total synthesis of diltiazem and Taxol™ side-chain
    Adger, BM
    Barkley, JV
    Bergeron, S
    Cappi, MW
    Flowerdew, BE
    Jackson, MP
    McCague, R
    Nugent, TC
    Roberts, SM
    [J]. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1997, (23): : 3501 - 3507
  • [2] Julia-Colonna asymmetric epoxidation reactions under non-aqueous conditions: Rapid, highly regio- and stereo-selective transformations using a cheap, recyclable catalyst
    Allen, JV
    Bergeron, S
    Griffiths, MJ
    Mukherjee, S
    Roberts, SM
    Williamson, NM
    Wu, LE
    [J]. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1998, (19): : 3171 - 3179
  • [3] Solid-phase synthesis of aryl ethers on high loading dendrimer resin
    Basso, A
    Evans, B
    Pegg, N
    Bradley, M
    [J]. TETRAHEDRON LETTERS, 2000, 41 (19) : 3763 - 3767
  • [4] Asymmetric epoxidation of enones employing polymeric alpha-amino acids in non-aqueous media
    Bentley, PA
    Bergeron, S
    Cappi, MW
    Hibbs, DE
    Hursthouse, MB
    Nugent, TC
    Pulido, R
    Roberts, SM
    Wu, LE
    [J]. CHEMICAL COMMUNICATIONS, 1997, (08) : 739 - 740
  • [5] Pd-catalyzed synthesis of a tethered soluble polymeric phosphine ligand
    Bergbreiter, DE
    Liu, YS
    Furyk, S
    Case, BL
    [J]. TETRAHEDRON LETTERS, 1998, 39 (48) : 8799 - 8802
  • [6] Water-soluble polymer-bound, recoverable palladium(0)-phosphine catalysts
    Bergbreiter, DE
    Liu, YS
    [J]. TETRAHEDRON LETTERS, 1997, 38 (45) : 7843 - 7846
  • [7] Synthesis of highly branched block copolymers of enantiomerically pure amino acids
    Birchall, AC
    North, M
    [J]. CHEMICAL COMMUNICATIONS, 1998, (13) : 1335 - 1336
  • [8] Biomimetic synthesis of ordered silica structures mediated by block copolypeptides
    Cha, JN
    Stucky, GD
    Morse, DE
    Deming, TJ
    [J]. NATURE, 2000, 403 (6767) : 289 - 292
  • [9] Polymer-supported cobalt carbonyl complexes as novel solid-phase catalysts of the Pauson-Khand reaction
    Comely, AC
    Gibson, SE
    Hales, NJ
    [J]. CHEMICAL COMMUNICATIONS, 2000, (04) : 305 - 306
  • [10] Facile synthesis of block copolypeptides of defined architecture
    Deming, TJ
    [J]. NATURE, 1997, 390 (6658) : 386 - 389