Anti-inflammatory and anti-angiogenic activities of Gastrodia elata Blume

被引：113

作者：

Ahn, Eun-Kyoung ^{[1
]}

Jeon, Hye-Jin ^{[1
]}

Lim, Eun-Ju ^{[1
]}

Jung, Hyun-Joo ^{[1
]}

Park, Eun-Hee ^{[1
]}

机构：

[1] Sookmyung Womens Univ, Coll Pharm, Seoul 140742, South Korea

来源：

JOURNAL OF ETHNOPHARMACOLOGY | 2007年 / 110卷 / 03期

关键词：

Gastrodia elata; analgesic; anti-angiogenic; anti-inflammatory; inducible nitric oxide synthase; nitric oxide;

D O I：

10.1016/j.jep.2006.10.006

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

Gastrodia elata Blume rhizome has been traditionally used as a folk medicine for centuries in Oriental countries. Its ethanol extract (GEE) and subsequent fractions were used to evaluate anti-angiogenic, anti-inflammatory and related activities of Gastrodia elata. GEE potently inhibited angiogenesis in the chick chorioallantoic membrane assay, and its n-butanol fraction (BuOH) exerted the higher inhibitory effect. In a dose-dependent manner, GEE inhibited vascular permeability induced by acetic acid. GEE and its BuOH fraction exerted an inhibitory activity on exudate production, leukocyte migration and nitric oxide (NO) level in rat air-pouch model. GEE caused a dose-dependent inhibition of acetic acid-induced abdominal writhing in mice. In addition, GEE inhibited NO production and expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) upon stimulation by lipopolysaccharide (LPS) in RAW264.7 macrophages. In summary, we demonstrate some novel pharmacological activities of Gastrodia elata, such as anti-angiogenic, anti-inflammatory and analgesic activities, and in vivo and in vitro inhibitory activity on NO production. (c) 2006 Elsevier Ireland Ltd. All rights reserved.

引用

页码：476 / 482

页数：7

共 23 条

[1]

Gastrodin decreases immunoreactivities of γ-aminobutyric acid shunt enzymes in the hippocampus of seizure-sensitive gerbils [J].