Improved biotransformations on charged PEGA supports

被引：21

作者：

Basso, A

De Martin, L

Gardossi, L

Margetts, G

Brazendale, I

Bosma, AY

Ulijn, RV

Flitsch, SL

机构：

[1] Univ Trieste, Dipartimento Sci Farmaceut, I-34127 Trieste, Italy

[2] Polymer Labs Ltd, Church Stretton, Shrops, England

[3] Univ Edinburgh, Sch Chem, Edinburgh Ctr Prot Technol, Edinburgh EH9 3JJ, Midlothian, Scotland

来源：

CHEMICAL COMMUNICATIONS | 2003年 / 11期

关键词：

D O I：

10.1039/b301680c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

PEGA supports functionalised with permanent charges show superior swelling properties in aqueous media when compared to neutral PEGA; a novel positively charged PEGA resin significantly improves penicillin G amidase (PGA) catalysed biotransformation on solid support, by favouring accessibility of the negatively charged enzyme.

引用

页码：1296 / 1297

页数：2

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