Nitrogen-containing Heterocyclic quinones: A class of potential selective antitumor agents

被引：79

作者：

Garuti, Laura ^{[1
]}

Roberti, Marinella ^{[1
]}

Pizzirani, Daniela ^{[1
]}

机构：

[1] Univ Bologna, Dept Pharmaceut Sci, I-40126 Bologna, Italy

来源：

MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2007年 / 7卷 / 05期

关键词：

quinones; anticancer agents; tumor-selective toxicity; SAR; prodrugs; heterocycles; CYTOTOXICITY IN-VITRO; INDOLEQUINONE PHOSPHORAMIDATE PRODRUGS; DT-DIAPHORASE; CELL-CYCLE; BIOLOGICAL EVALUATION; NAD(P)H-QUINONE OXIDOREDUCTASE; CDC25; PHOSPHATASES; TOPOISOMERASE-II; CANCER-THERAPY; ANTIPROLIFERATIVE ACTIVITY;

D O I：

10.2174/138955707780619626

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The development of prodrugs that are enzymatically activated into anticancer agents is a promising perspective in cancer therapy. Many nitrogen-containing quinoid heterocycles have been reported to show antitumor effect. The principal interest in these compounds lies on their potential to produce tumor-selective toxicity. Selectivity occurs by difference in oxygen tension between normal and tumor tissue and by levels of the required activating enzymes.

引用

页码：481 / 489

页数：9

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