Expression and function of HLA-DQ8 (DQA10301/DQB10302) genes in transgenic mice

被引：47

作者：

Cheng, S ^{[1
]}

Baisch, J ^{[1
]}

Krco, C ^{[1
]}

Savarirayan, S ^{[1
]}

Hanson, J ^{[1
]}

Hodgson, K ^{[1
]}

Smart, M ^{[1
]}

David, C ^{[1
]}

机构：

[1] MAYO CLIN & MAYO FDN,DEPT IMMUNOL,ROCHESTER,MN 55905

来源：

EUROPEAN JOURNAL OF IMMUNOGENETICS | 1996年 / 23卷 / 01期

关键词：

D O I：

10.1111/j.1744-313X.1996.tb00260.x

中图分类号：

Q3 [遗传学];

学科分类号：

071007 [遗传学]; 090102 [作物遗传育种];

摘要：

Transgenic mice expressing HLA-DQA1*0301 and HLA-DQB1*0302 genes (DQ8) were produced. The transgenes were then transferred into mouse (Ab degrees) class II negative mice: the only class II molecules expressed in these animals were therefore coded by the HLA-DQ8 genes. Good expression of HLA-DQ molecules was found. Both CD4+ T cells and DQ8-specific T-cell receptor VP expressing cells were positively selected in these mice. The HLA-DQ8 molecules expressed in these animals can present various foreign and self antigens and induce T-cell proliferation in vitro. These mice will be invaluable in future studies of the structure and function of HLA-DQ8 genes.

引用

页码：15 / 20

页数：6

共 9 条

[1]

MICE LACKING MHC CLASS-II MOLECULES [J].