Whole-Body MR Imaging in the German National Cohort:Rationale, Design, and Technical Background

被引：139

作者：

Bamberg, Fabian ^{[1
,2
]}

Kauczor, Hans-Ulrich ^{[3
]}

Weckbach, Sabine ^{[3
]}

Schlett, Christopher L. ^{[3
]}

Forsting, Michael ^{[4
,5
]}

Ladd, Susanne C. ^{[4
,5
]}

Greiser, Karin Halina ^{[6
]}

Weber, Marc-Andre ^{[3
]}

Schulz-Menger, Jeanette ^{[7
,8
]}

Niendorf, Thoralf ^{[9
]}

Pischon, Tobias ^{[10
]}

Caspers, Svenja ^{[11
]}

Amunts, Katrin ^{[11
,12
,13
]}

Berger, Klaus ^{[14
]}

Buelow, Robin ^{[15
]}

Hosten, Norbert ^{[15
]}

Hegenscheid, Katrin ^{[15
]}

Kroencke, Thomas ^{[16
]}

Linseisen, Jakob ^{[17
]}

Guenther, Matthias ^{[20
]}

Hirsch, Jochen G. ^{[20
]}

Koehn, Alexander ^{[20
]}

Hendel, Thomas ^{[2
]}

Wichmann, Heinz-Erich ^{[17
,18
,19
]}

Schmidt, Boege ^{[21
]}

Joeckel, Karl-Heinz ^{[21
]}

Hoffmann, Wolfgang ^{[22
]}

Kaaks, Rudolf ^{[6
]}

Reiser, Maximilian F. ^{[2
]}

Voelzke, Henry ^{[22
]}

机构：

[1] Univ Tubingen Hosp, Dept Diagnost & Intervent Radiol, Tubingen, Germany

[2] Univ Munich, Klinikum Grosshadern, Dept Clin Radiol, D-80539 Munich, Germany

[3] Heidelberg Univ, Dept Diagnost & Intervent Radiol, Univ Heidelberg Hosp, Heidelberg, Germany

[4] Univ Duisburg Essen, Dept Diagnost & Intervent Radiol, Univ Hosp Essen, Essen, Germany

[5] Univ Duisburg Essen, Neuroradiol, Univ Hosp Essen, Essen, Germany

[6] German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany

[7] ECRC Univ Med Berlin, Charite Campus Buch, Berlin, Germany

[8] HELIOS Klin, Klin Kardiol & Nephrol, Berlin, Germany

[9] Max Delbruck Ctr Mol Med, BUFF, Berlin, Germany

[10] Max Delbruck Ctr Mol Med MDC, Epidemiol Res Grp, Berlin, Germany

[11] Julich Res Ctr, Inst Neurosci & Med INM 1, Julich, Germany

[12] Univ Dusseldorf, C&O Vogt Inst Brain Res, Dusseldorf, Germany

[13] Julich Aachen Res Alliance, JARA BRAIN, Julich, Germany

[14] Univ Munster, Inst Epidemiol & Social Med, D-48149 Munster, Germany

[15] Univ Greifswald, Dept Radiol & Neuroradiol, Univ Med Greifswald, Greifswald, Germany

[16] Klinikum Augsburg, Klin Diagnost & Intervent Radiol & Neuroradiol, Augsburg, Germany

[17] German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Munich, Germany

[18] Univ Munich, Inst Med Informat Biometry & Epidemiol, Munich, Germany

[19] Tech Univ Munich, Inst Med Stat & Epidemiol, D-80290 Munich, Germany

[20] Fraunhofer Inst Med Image Comp MEVIS, Bremen, Germany

[21] Univ Duisburg Essen, Univ Hosp Essen, Inst Med Informat Biometry & Epidemiol, Essen, Germany

[22] Univ Greifswald, Inst Community Med, Greifswald, Germany

来源：

RADIOLOGY | 2015年 / 277卷 / 01期

关键词：

CARDIOVASCULAR-MAGNETIC-RESONANCE; STATE FUNCTIONAL CONNECTIVITY; CORONARY-HEART-DISEASE; INCIDENTAL FINDINGS; ARTERIAL STIFFNESS; HEALTHY-VOLUNTEERS; WORKING GROUP; RISK-FACTORS; QUANTIFICATION; ANGIOGRAPHY;

D O I：

10.1148/radiol.2015142272

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

100231 [临床病理学]; 100902 [航空航天医学];

摘要：

Purpose: To detail the rationale, design, and future perspective of implementing whole-body magnetic resonance (MR) imaging in the German National Cohort, a large multicentric population-based study. Materials and Methods: All institutional review boards approved the study, and informed consent is obtained before study enrollment. Participants are enrolled from a random sample of the general population at five dedicated imaging sites among 18 recruitment centers. MR imaging facilities are equipped with identical 3.0-T imager technology and use uniform MR protocols. Imager-specific hardware and software settings remained constant over the study period. On-site and centralized measures of image quality enable monitoring of completeness of the acquisitions and quality of each of the MR sequences. Certified radiologists read all MR imaging studies for presence of incidental findings according to predefined algorithms. Results: Over a 4-year period, six participants per day are examined at each center, totaling a final imaging cohort of approximately 30 000 participants. The MR imaging protocol is identical for each site and comprises a set of 12 native series to cover neurologic, cardiovascular, thoracoabdominal, and musculoskeletal imaging phenotypes totaling approximately 1 hour of imaging time. A dedicated analysis platform as part of a central imaging core incorporates a thin client-based integrative and modular data handling platform to enable multicentric off-site image reading for incidental findings. Scientific analysis will be pursued on a per-project hypothesis-driven basis. Conclusion: Population-based whole-body MR imaging as part of the German National Cohort will serve to compile a comprehensive image repository, will provide insight into physiologic variants and subclinical disease burden, and has the potential to enable identification of novel imaging biomarkers of risk. (C) RSNA, 2015

引用

页码：206 / 220

页数：15

共 58 条

[1]

[Anonymous], 2011, MAN INC FIND DET RES

[2]

Whole-body dual-modality PET/CT and whole-body MRI for tumor staging in oncology [J].