Corrosion of, and cellular responses to Mg-Zn-Ca bulk metallic glasses

被引：353

作者：

Gu, Xuenan ^{[1
,2
]}

Zheng, Yufeng ^{[1
,2
,3
]}

Zhong, Shengping ^{[3
]}

Xi, Tingfei ^{[3
]}

Wang, Junqiang ^{[4
]}

Wang, Weihua ^{[4
]}

机构：

[1] Peking Univ, Coll Engn, State Key Lab Turbulence & Complex Syst, Beijing 100871, Peoples R China

[2] Peking Univ, Coll Engn, Dept Adv Mat & Nanotechnol, Beijing 100871, Peoples R China

[3] Peking Univ, Ctr Biomed Mat & Tissue Engn, Acad Adv Interdisciplinary Studies, Beijing 100871, Peoples R China

[4] Chinese Acad Sci, Inst Phys, Beijing 100080, Peoples R China

来源：

BIOMATERIALS | 2010年 / 31卷 / 06期

基金：

中国国家自然科学基金;

关键词：

Magnesium alloy; Bulk metallic glass; Mechanical property; Corrosion; Cytotoxicity; IN-VIVO CORROSION; MAGNESIUM ALLOYS; MECHANICAL-PROPERTIES; VITRO DEGRADATION; BONE; BEHAVIOR; BIOMATERIALS; STRENGTH;

D O I：

10.1016/j.biomaterials.2009.11.015

中图分类号：

R318 [生物医学工程];

学科分类号：

100103 [病原生物学];

摘要：

Mg-Zn-Ca bulk metallic glass with different compositions (Mg66Zn30Ca4 and Mg70Zn25Ca5) have been prepared for this study and their feasibility as biodegradable metallic materials have been evaluated by the microstructural, surface analysis, mechanical testing, corrosion and cytotoxicity tests It was. found that the Mg66Zn30Ca4 sample presents a more uniform corrosion morphology than as-rolled pure Mg and Mg70Zn25Ca5 samples, with much smaller micro-scale uniformly distributed pores beneath the corrosion product layer. The corrosion products were identified to be Mg(OH)(2) and Zn(OH)(2), and a uniform corrosion mechanism is proposed. Both indirect cytotoxicity and direct cell culture experiments were carried out using L929 and MG63 cell lines. The results show higher cell viabilities for Mg-Zn-Ca extracts than that for as-rolled pure Mg. In addition, L929 and MG63 cells were found to adhere and proliferate on the surface of Mg66Zn30Ca4 sample. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：1093 / 1103

页数：11

共 40 条

[1]

[Anonymous], 1999, ANN BOOK ASTM STAND, V03.01

[2]

Corrosion behaviour of Mg65Cu7.5Ni7.5Ag5Zn5Gd5Y5 bulk metallic glass in aqueous environments [J].