Creatine monohydrate in myotonic dystrophy -: A double-blind, placebo-controlled clinical study

被引：48

作者：

Walter, MC ^{[1
]}

Reilich, P ^{[1
]}

Lochmüller, H ^{[1
]}

Kohnen, R ^{[1
]}

Schlotter, B ^{[1
]}

Hautmann, H ^{[1
]}

Dunkl, E ^{[1
]}

Pongratz, D ^{[1
]}

Müller-Felber, W ^{[1
]}

机构：

[1] Univ Munich, Friedrich Baur Inst, Dept Neurol, D-80336 Munich, Germany

来源：

JOURNAL OF NEUROLOGY | 2002年 / 249卷 / 12期

关键词：

myotonic dystrophy (MD); creatine monohydrate; therapy; supplementation;

D O I：

10.1007/s00415-002-0923-x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We assessed safety and efficacy of creatine monohydrate (Cr) in myotonic dystrophy (DM1) in a double-blind, cross-over trial. Thirty-four patients with defined DM1 were randomized to receive Cr and placebo for eight weeks (10.6 g day 1-10, 5.3 g day 11-56) in one of 2 treatment sequences. There was no significant improvement using manual and quantitative muscle strength, daily-life activities, and patients' own global assessment comparing verum with placebo administration. Cr supplementation was well tolerated without clinically relevant side effects, but did not result in significant improvement of muscle strength or daily-life activities.

引用

页码：1717 / 1722

页数：6

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