Supramolecular catalysis of a unimolecular transformation: Aza-cope rearrangement within a self-assembled host

被引：260

作者：

Fiedler, D ^{[1
]}

Bergman, RG ^{[1
]}

Raymond, KN ^{[1
]}

机构：

[1] Univ Calif Berkeley, Dept Chem, Berkeley, CA 94720 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2004年 / 43卷 / 48期

关键词：

cage compounds; homogeneous catalysis; host-guest systems; sigmatropic rearrangement;

D O I：

10.1002/anie.200461776

中图分类号：

O6 [化学];

学科分类号：

0703 [化学];

摘要：

Catalytic containers: A supramolecular metal-ligand assembly [M 4L6] is utilized as a catalytic host for the unimolecular carbon-carbon bond-forming rearrangement of enammonium cations (see scheme). The restricted reaction space of the supramolecular structure forces the substrate to adopt a reactive conformation upon binding to the interior. The assembly achieves up to 850-fold rate acceleration of the rearrangement.

引用

页码：6748 / 6751

页数：4

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