Quantitation of film coating Zanta® 75 mg tablets and Epivir HBV® 100 mg tablets by ICP-AES

被引：7

作者：

Incledon, C ^{[1
]}

Paquet, C ^{[1
]}

Johnston, A ^{[1
]}

Jairam, R ^{[1
]}

Dass, L ^{[1
]}

Lam, H ^{[1
]}

机构：

[1] GlaxoSmithKline Inc, Pharmaceut Dev Dept, Mississauga, ON L5N 6L4, Canada

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 2003年 / 31卷 / 03期

关键词：

inductively coupled plasma; tablet coating analysis; quantitation of film coating; titanium analysis; atomic emission spectroscopy;

D O I：

10.1016/S0731-7085(02)00332-1

中图分类号：

O65 [分析化学];

学科分类号：

070302 [分析化学]; 081704 [应用化学];

摘要：

Purpose: To present a selective analytical Inductively Coupled Plasma-Atomic Emission Spectroscopy (ICP-AES) method developed and validated for the quantitation of tablet film coatings containing titanium. Methods: Tablet samples were decomposed by either digestion or dry ashing. The amount of film tablet coating was calculated based on titanium content of the sample. Results: The reported ICP-AES method was accurate, precise, sensitive and linear for determination of titanium concentrations from 2.9 to 8.6 ppm. Conclusion: This method provides an accurate determination of the amount of coating on a tablet and has general applicability for a variety of coating formulations containing different elements. (C) 2003 Elsevier Science B.V. All rights reserved.

引用

页码：413 / 420

页数：8

共 10 条

[1]

*COL BERW PHARM SE, 1996, YS1117307A COL BERW

[2]

*COL BERW PHARM SE, 1996, QUANT FORM OP PINK

[3]

QUANTITATION OF INK TRANSFERRED DURING PHARMACEUTICAL PRINTING OPERATIONS USING INDUCTIVELY-COUPLED PLASMA-ATOMIC EMISSION-SPECTROSCOPY [J].

DUNN, K ;

GARCIA, T ;

HILBORN, R ;

KRISTOF, J ;

STEELE, A ;

WILBOURNE, DK .

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 1995, 21 (04) :487-494

[4]

TITANIUM DETERMINATION AS A METHOD OF QUANTIFYING FILM-COAT APPLICATION ON TO TABLETS [J].

HARRISON, JJ ;

LAFFERTY, I ;

MOORE, WD ;

RAWLINS, DA ;

RISSEN, NR ;

THWAITES, PM .

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 1991, 17 (01) :149-155

[5]

Houk R., 1986, ANAL CHEM, V58, P97

[6]

Near-infrared spectroscopic monitoring of the film coating process [J].

Kirsch, JD ;

Drennen, JK .

PHARMACEUTICAL RESEARCH, 1996, 13 (02) :234-237

[7]

DETERMINATION OF FILM-COATED TABLET PARAMETERS BY NEAR-INFRARED SPECTROSCOPY [J].

KIRSCH, JD ;

DRENNEN, JK .

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 1995, 13 (10) :1273-1281

[8]

A HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC METHOD FOR THE DETERMINATION OF THE AMOUNT OF HYDROXYPROPYL METHYLCELLULOSE APPLIED TO TABLETS DURING AN AQUEOUS FILM COATING OPERATION [J].

MACLAREN, DD ;

HOLLENBECK, RG .

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 1987, 13 (12) :2179-2197

[9]

MOORE GL, 1989, INTRO INDUCTIVELY CO, P121

[10]

Skoog D.A., 1992, FUNDAMENTALS ANAL CH, V6th

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