Epoxyalkanoyls as novel ACE inhibitors

被引：1

作者：

Choo, HYP ^{[1
]}

Yoon, HR

Park, HS

Kim, DH

Park, J

Kim, J

机构：

[1] Ewha Womans Univ, Sch Pharm, Seoul 120750, South Korea

[2] Korea Inst Sci & Technol, Doping Control Ctr, Seoul 130650, South Korea

[3] Pohang Univ Sci & Technol, Dept Chem, Pohang 790784, South Korea

来源：

ARCHIVES OF PHARMACAL RESEARCH | 1998年 / 21卷 / 02期

关键词：

epoxides; angiotensin converting enzyme inhibitor; irreversible inhibition;

D O I：

10.1007/BF02974023

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The epoxyalkanoyl derivatives were designed and synthesized as ACE inhibitors. Coupling of unsaturated carboxylic acids with amino acids and following epoxidation with dimethyldioxirane gave the epoxyalkanoyls with high yield. The inhibitory activity of synthesized compounds on angiotensin converting enzyme was IC50 values of 0.06 similar to 5.5 mu M.

引用

页码：168 / 173

页数：6

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