Chemical genetics: tailoring tools for cell biology

被引：73

作者：

Mayer, TU ^{[1
]}

机构：

[1] Max Planck Inst Biochem, Dept Cell Biol, D-82152 Martinsried, Germany

来源：

TRENDS IN CELL BIOLOGY | 2003年 / 13卷 / 05期

关键词：

D O I：

10.1016/S0962-8924(03)00077-1

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Chemical genetics is a research approach that uses small molecules as probes to study protein functions in cells or whole organisms. Here, I review the parallels between classical genetic and chemical-genetic approaches and discuss the merits of small molecules to dissect dynamic cellular processes. I then consider the pros and cons of different screening approaches and specify strategies aimed at identifying and validating cellular target proteins. Finally, I highlight the impact of chemical genetics on our current understanding of cell biology and its potential for the future.

引用

页码：270 / 277

页数：8

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