Cellular neurophysiological actions of nociceptin/orphanin FQ

被引：56

作者：

Moran, TD

Abdulla, FA

Smith, PA

机构：

[1] Univ Alberta, Div Neurosci, Edmonton, AB T6G 2H7, Canada

[2] Univ Alberta, Dept Pharmacol, Edmonton, AB T6G 2H7, Canada

[3] Tennessee State Univ, Dept Phys Therapy, Nashville, TN 37290 USA

来源：

PEPTIDES | 2000年 / 21卷 / 07期

基金：

英国医学研究理事会;

关键词：

analgesic; calcium channel; dorsal root ganglion; dorsal horn; morphine; neuropathic pain; nociceptin; opioid; orphan opioid-like receptor; potassium channel; substantia gelatinosa;

D O I：

10.1016/S0196-9781(00)00235-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cellular actions of nociceptin/orphanin FQ (N/OFQ) resemble those of mu-, delta-, and kappa-opioids, i.e. activation of inwardly rectifying K+ conductance, inhibition of high-voltage-activated Ca2+ channel currents, and impediment of neurotransmitter release. Differences in ORL1 and mu-receptor distribution lead to: 1) more widespread actions of N/OFQ on periaqueductal gray neurons than opioids acid 2) differential effects of N/OFQ and opioids in the brainstem. Also, unlike opioids, N/OFQ inhibits T-type Ca2+ channel current in sensory neurons. Opioids and N/OFQ may modulate glutamate responses in different ways, and certain actions of N/OFQ are potentiated following nerve injury whereas those of mu-opioids are attenuated. Agonists at ORL, receptors may therefore be of clinical interest in the management of neuropathic pain. (C) 2000 Elsevier Science Inc. All rights reserved.

引用

页码：969 / 976

页数：8

共 86 条

[61] ACTIVATION OF MU-OPIOID RECEPTORS INHIBITS TRANSIENT HIGH-THRESHOLD AND LOW-THRESHOLD CA2+ CURRENTS, BUT SPARES A SUSTAINED CURRENT [J].