Region 4 of σ as a target for transcription regulation

被引：87

作者：

Dove, SL

Darst, SA

Hochschild, A ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Dept Microbiol & Mol Genet, Boston, MA 02115 USA

[2] Harvard Univ, Childrens Hosp, Sch Med, Div Infect Dis, Boston, MA 02115 USA

[3] Rockefeller Univ, New York, NY 10021 USA

来源：

MOLECULAR MICROBIOLOGY | 2003年 / 48卷 / 04期

关键词：

D O I：

10.1046/j.1365-2958.2003.03467.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Bacterial sigma factors play a key role in promoter recognition, making direct contact with conserved promoter elements. Most sigma factors belong to the sigma(70) family, named for the primary sigma factor in Escherichia coli . Members of the sigma(70) family typically share four conserved regions and, here, we focus on region 4, which is directly involved in promoter recognition and serves as a target for a variety of regulators of transcription initiation. We review recent advances in the understanding of the mechanism of action of regulators that target region 4 of sigma.

引用

收藏

页码：863 / 874

页数：12

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