Actin complexes in the cell nucleus: new stones in an old field

被引：50

作者：

Castano, E. ^{[1
,2
]}

Philimonenko, V. V. ^{[1
]}

Kahle, M. ^{[1
]}

Fukalova, J. ^{[1
]}

Kalendova, A. ^{[1
]}

Yildirim, S. ^{[1
]}

Dzijak, R. ^{[1
]}

Dingova-Krasna, H. ^{[1
]}

Hozak, P. ^{[1
]}

机构：

[1] ASCR, Inst Mol Genet, Dept Biol Cell Nucleus, Vvi, Prague 14220 4, Czech Republic

[2] CICY, Biochem & Mol Plant Biol Dept, Merida 97200, Yucatan, Mexico

来源：

HISTOCHEMISTRY AND CELL BIOLOGY | 2010年 / 133卷 / 06期

关键词：

Actin; Actin-binding proteins; Cell nucleus; Chromatin; Transcription; Replication; Nucleocytoplasmic transport; Nucleoskeleton; Regulation; RNA-POLYMERASE-II; CHROMATIN-REMODELING COMPLEX; INTERSTRAND CROSS-LINKS; ABL TYROSINE KINASE; DNA-DAMAGE RESPONSE; ALPHA-SPECTRIN-II; A-TYPE LAMINS; FLIGHTLESS-I; MYOSIN-I; F-ACTIN;

D O I：

10.1007/s00418-010-0701-2

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Actin is a well-known protein that has shown a myriad of activities in the cytoplasm. However, recent findings of actin involvement in nuclear processes are overwhelming. Actin complexes in the nucleus range from very dynamic chromatin-remodeling complexes to structural elements of the matrix with single partners known as actin-binding proteins (ABPs). This review summarizes the recent findings of actin-containing complexes in the nucleus. Particular attention is given to key processes like chromatin remodeling, transcription, DNA replication, nucleocytoplasmic transport and to actin roles in nuclear architecture. Understanding the mechanisms involving ABPs will definitely lead us to the principles of the regulation of gene expression performed via concerting nuclear and cytoplasmic processes.

引用

页码：607 / 626

页数：20

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