Vitamin C supplementation does not alter the immune response to 2.5 hours of running

被引:55
作者
Nieman, DC
Henson, DA
Butterworth, DE
Warren, BJ
Davis, JM
Fagoaga, OR
NehlsenCannarella, SL
机构
[1] APPALACHIAN STATE UNIV, DEPT BIOL, BOONE, NC 28608 USA
[2] UNIV S CAROLINA, DEPT EXERCISE SCI, SCH PUBL HLTH, COLUMBIA, SC 29208 USA
[3] LOMA LINDA UNIV, MED CTR, CTR IMMUNOL, LOMA LINDA, CA 92350 USA
来源
INTERNATIONAL JOURNAL OF SPORT NUTRITION | 1997年 / 7卷 / 03期
关键词
lymphocytes; cortisol; interleukin-6; phagocytosis; natural killer cell activity; lymphocyte proliferation;
D O I
10.1123/ijsn.7.3.173
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
This randomized, double-blind, placebo-controlled study was designed to determine the influence of vitamin C supplementation on the immune response to 2.5 hr of high-intensity running. Twelve experienced marathon runners (VO2 max 51.6 +/- 1.5 ml.kg(-1).min(-1), age 40.5 +/- 2.0 years) were randomized into vitamin C (1,000 mg/day for 8 days) or placebo groups. On the test day, subjects ran at 75-80% VO2 max for 2.5 hr, with five blood samples taken before and for 6 hr after. Blood samples were analyzed for cortisol and catecholamines; leukocyte subsets; interleukin-6; natural killer cell activity; lymphocyte proliferation as induced by concanavalin A, phytohemagglutinin, and pokeweed mitogen; and granulocyte phagocytosis and activated oxidative burst. Compared with placebo, vitamin C supplementation had no significant effect on the pattern of change in any of these hormonal or immune measures following 2.5 hr of intensive running.
引用
收藏
页码:173 / 184
页数:12
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