Oxygen-dependent regulation of hypoxia-inducible factors by prolyl and asparaginyl hydroxylation

被引：105

作者：

Lando, D

Gorman, JJ

Whitelaw, ML

Peet, DJ ^{[1
]}

机构：

[1] Univ Adelaide, Dept Mol Biosci Biochem, Adelaide, SA 5005, Australia

[2] Univ Adelaide, Ctr Mol Genet Dev, Adelaide, SA 5005, Australia

[3] CSIRO Hlth Sci & Nutr, Parkville, Vic, Australia

来源：

EUROPEAN JOURNAL OF BIOCHEMISTRY | 2003年 / 270卷 / 05期

关键词：

oxygen sensing; hypoxia; hydroxylation; transcriptional regulation; hypoxia-inducible factor (HIF);

D O I：

10.1046/j.1432-1033.2003.03445.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

To sustain life mammals have an absolute and continual requirement for oxygen, which is necessary to produce energy for normal cell survival and growth. Hence, maintaining oxygen homeostasis is a critical requirement and mammals have evolved a wide range of cellular and physiological responses to adapt to changes in oxygen availability. In the past few years it has become evident that the transcriptional protein complex hypoxia-inducible factor (HIF) is a key regulator of these processes. In this review we will focus on the way oxygen availability regulates HIF proteins and in particular we will discuss the way oxygen-dependent hydroxylation of specific amino acid residues has been demonstrated to regulate HIF function at the level of both protein stability and transcriptional potency.

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收藏

页码：781 / 790

页数：10

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