Oxygen-dependent regulation of hypoxia-inducible factors by prolyl and asparaginyl hydroxylation

被引：105

作者：

Lando, D

Gorman, JJ

Whitelaw, ML

Peet, DJ ^{[1
]}

机构：

[1] Univ Adelaide, Dept Mol Biosci Biochem, Adelaide, SA 5005, Australia

[2] Univ Adelaide, Ctr Mol Genet Dev, Adelaide, SA 5005, Australia

[3] CSIRO Hlth Sci & Nutr, Parkville, Vic, Australia

来源：

EUROPEAN JOURNAL OF BIOCHEMISTRY | 2003年 / 270卷 / 05期

关键词：

oxygen sensing; hypoxia; hydroxylation; transcriptional regulation; hypoxia-inducible factor (HIF);

D O I：

10.1046/j.1432-1033.2003.03445.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

To sustain life mammals have an absolute and continual requirement for oxygen, which is necessary to produce energy for normal cell survival and growth. Hence, maintaining oxygen homeostasis is a critical requirement and mammals have evolved a wide range of cellular and physiological responses to adapt to changes in oxygen availability. In the past few years it has become evident that the transcriptional protein complex hypoxia-inducible factor (HIF) is a key regulator of these processes. In this review we will focus on the way oxygen availability regulates HIF proteins and in particular we will discuss the way oxygen-dependent hydroxylation of specific amino acid residues has been demonstrated to regulate HIF function at the level of both protein stability and transcriptional potency.

引用

收藏

页码：781 / 790

页数：10

相关论文

共 121 条

[31] Hypoxia-inducible factor 1-dependent induction of intestinal trefoil factor protects barrier function during hypoxia [J].

Furuta, GT ;

Turner, JR ;

Taylor, CT ;

Hershberg, RM ;

Comerford, K ;

Narravula, S ;

Podolsky, DK ;

Colgan, SP .

JOURNAL OF EXPERIMENTAL MEDICINE, 2001, 193 (09) :1027-1034

[32] Differential transcriptional regulation of the two vascular endothelial growth factor receptor genes - Flt-1, but not Flk-1/KDR, is up-regulated by hypoxia [J].

Gerber, HP ;

Condorelli, F ;

Park, J ;

Ferrara, N .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (38) :23659-23667

[33] Identification of an oxygen responsive enhancer element in the glyceraldehyde-3-phosphate dehydrogenase gene [J].

Graven, KK ;

Yu, Q ;

Pan, D ;

Roncarati, JS ;

Farber, HW .

BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION, 1999, 1447 (2-3) :208-218

[34]

Gu YZ, 1998, GENE EXPRESSION, V7, P205

[35] Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family [J].

Hewitson, KS ;

McNeill, LA ;

Riordan, MV ;

Tian, YM ;

Bullock, AN ;

Welford, RW ;

Elkins, JM ;

Oldham, NJ ;

Bhattacharya, S ;

Gleadle, JM ;

Ratcliffe, PJ ;

Pugh, CW ;

Schofield, CJ .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (29) :26351-26355

[36] Rac1 activity is required for the activation of hypoxia-inducible factor 1 [J].

Hirota, K ;

Semenza, GL .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (24) :21166-21172

[37] Structural basis for the recognition of hydroxyproline in αIF-1α by pVHL [J].

Hon, WC ;

Wilson, MI ;

Harlos, K ;

Claridge, TDW ;

Schofield, CJ ;

Pugh, CW ;

Maxwell, PH ;

Ratcliffe, PJ ;

Stuart, DI ;

Jones, EY .

NATURE, 2002, 417 (6892) :975-978

[38] Hypoxia regulates expression of the endothelin-1 gene through a proximal hypoxia-inducible factor-1 binding site on the antisense strand [J].

Hu, J ;

Discher, DJ ;

Bishopric, NH ;

Webster, KA .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1998, 245 (03) :894-899

[39] Sequence determinants in hypoxia-inducible factor-1α for hydroxylation by the prolyl hydroxylases PHD1, PHD2, and PHD3 [J].

Huang, JH ;

Zhao, Q ;

Mooney, SM ;

Lee, FS .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (42) :39792-39800

[40] Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its alpha subunit [J].

Huang, LE ;

Arany, Z ;

Livingston, DM ;

Bunn, HF .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (50) :32253-32259

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