Decreased soluble interleukin-6 receptor in cerebrospinal fluid of patients with Alzheimer's disease

被引：39

作者：

Hampel, H

Sunderland, T

Kötter, HU

Schneider, C

Teipel, SJ

Padberg, F

Dukoff, R

Levy, J

Möller, HJ

机构：

[1] Univ Munich, Sch Med, Dept Psychiat, Geriatr Psychiat Branch, D-80336 Munich, Germany

[2] NIMH, NIH, Geriatr Psychiat Branch, Bethesda, MD 20892 USA

来源：

BRAIN RESEARCH | 1998年 / 780卷 / 02期

关键词：

Alzheimer's disease; cerebrospinal fluid; interleukin-6; soluble interleukin-6 receptor; family history; ELISA;

D O I：

10.1016/S0006-8993(97)01355-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The function of the cytokine interleukin-6 (IL-6) is augmented by soluble IL-6 receptors (sIL-6R). We investigated cerebrospinal fluid sIL-6R concentrations in patients with Alzheimer's disease (AD) compared to age-matched healthy subjects and individuals with at least one first degree relative with AD. We found a statistically significant decrease in sIL-6R levels in the AD group compared to controls. Complete analysis of the IL-6R complex seems crucial to better understand the impact of IL-6 in AD pathophysiology. (C) 1998 Elsevier Science B.V.

引用

页码：356 / 359

页数：4

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