Effect of venlafaxine on imipramine metabolism

被引：25

作者：

Albers, LJ

Reist, C

Vu, RL

Fujimoto, K

Ozdemir, V

Helmeste, D

Poland, R

Tang, SW

机构：

[1] Univ Calif Irvine, Coll Med, Dept Psychiat, Irvine, CA 92697 USA

[2] VA Healthcare Syst, Dept Mental Hlth, Long Beach, CA 90822 USA

[3] Univ Toronto, Dept Pharmacol, Toronto, ON, Canada

[4] Univ Toronto, Dept Psychiat, Toronto, ON, Canada

[5] Ctr Addict & Mental Hlth, Neurogenet Sect, Toronto, ON, Canada

[6] Harbor UCLA Med Ctr, Dept Psychiat, Torrance, CA 90509 USA

来源：

PSYCHIATRY RESEARCH | 2000年 / 96卷 / 03期

关键词：

antidepressant; tricyclic; desipramine; human cytochrome P450; pharmacokinetics; drug-drug interactions;

D O I：

10.1016/S0165-1781(00)00213-4

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

The present study was: designed to determine the effect of venlafaxine on imipramine metabolism in an attempt to elucidate the potential for cytochrome P450 drug-drug interactions with venlafaxine. We examined the metabolism of a single 100-mg dose of imipramine before and after treatment with venlafaxine, 50 mg three times a day. Eight male subjects were phenotyped for CYP2D6 activity. Two subjects were poor metabolizers of dextromethophan, and data from the remaining six subjects (mean age = 45.3 +/- 15) were analyzed. Venlafaxine increased imipramine C-max and elevated AUC by 40%. Desipramine clearance and volume of distribution were reduced by 20% and 25%, respectively. These findings are consistent with a statistically significant, but clinically modest impact of venlafaxine on CYP2D6-metabolized substrates. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：235 / 243

页数：9

共 36 条

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