Effect of venlafaxine on imipramine metabolism

被引:25
作者
Albers, LJ
Reist, C
Vu, RL
Fujimoto, K
Ozdemir, V
Helmeste, D
Poland, R
Tang, SW
机构
[1] Univ Calif Irvine, Coll Med, Dept Psychiat, Irvine, CA 92697 USA
[2] VA Healthcare Syst, Dept Mental Hlth, Long Beach, CA 90822 USA
[3] Univ Toronto, Dept Pharmacol, Toronto, ON, Canada
[4] Univ Toronto, Dept Psychiat, Toronto, ON, Canada
[5] Ctr Addict & Mental Hlth, Neurogenet Sect, Toronto, ON, Canada
[6] Harbor UCLA Med Ctr, Dept Psychiat, Torrance, CA 90509 USA
关键词
antidepressant; tricyclic; desipramine; human cytochrome P450; pharmacokinetics; drug-drug interactions;
D O I
10.1016/S0165-1781(00)00213-4
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
The present study was: designed to determine the effect of venlafaxine on imipramine metabolism in an attempt to elucidate the potential for cytochrome P450 drug-drug interactions with venlafaxine. We examined the metabolism of a single 100-mg dose of imipramine before and after treatment with venlafaxine, 50 mg three times a day. Eight male subjects were phenotyped for CYP2D6 activity. Two subjects were poor metabolizers of dextromethophan, and data from the remaining six subjects (mean age = 45.3 +/- 15) were analyzed. Venlafaxine increased imipramine C-max and elevated AUC by 40%. Desipramine clearance and volume of distribution were reduced by 20% and 25%, respectively. These findings are consistent with a statistically significant, but clinically modest impact of venlafaxine on CYP2D6-metabolized substrates. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码:235 / 243
页数:9
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