Preparation of sodium alginate-methylcellulose blend microspheres for controlled release of nifedivine

被引：126

作者：

Babu, V. Ramesh ^{[1
]}

Sairam, Malladi ^{[1
]}

Hosamani, Kallappa M. ^{[1
]}

Aminabhavi, Tejraj M. ^{[1
]}

机构：

[1] Karnatak Univ, Drug Delivery Div, Ctr Excellence Polymer Sci, Dharwad 580003, Karnataka, India

来源：

CARBOHYDRATE POLYMERS | 2007年 / 69卷 / 02期

关键词：

carbohydrate polymers; blend microspheres; nifedipine; controlled release;

D O I：

10.1016/j.carbpol.2006.09.027

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Carbohydrate polymeric blend microspheres, consisting of sodium alginate (NaAlg) and methylcellulose (MC) were prepared by water-in-oil (W/O) emulsion method. These microspheres were cross-linked with glutaraldehyde and loaded with nifedipine (NFD), an anti-inflammatory drug. The microspheres were characterized by differential scanning calorimetry (DSC), scanning electron microscopy (SEM) and laser particle size analyzer. DSC thermograms of NFD-loaded NaAlg-MC microspheres confirmed the molecular level distribution of NFD in the polymer matrix. SEM picture of the microspheres suggested the formation of spherical particles. Swelling experiments on the microspheres provided important information on drug diffusion properties. Release data have been analyzed using an empirical equation to understand the nature of transport of drug containing solution through the polymeric matrices. The controlled release characteristics of the matrices for NFD were investigated in pH 7.4 media. Particle size and size distribution of the microspheres was studied by laser light diffraction particle size analyzer. Drug was released in a controlled manner up to 12 h. (C) 2006 Elsevier Ltd. All rights reserved.

引用

页码：241 / 250

页数：10

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