Enhanced cell therapy strategy to treat chronic limb-threatening ischemia

被引：9

作者：

Eton, Darwin ^{[1
,2
,3
]}

Yu, Hong ^{[2
,3
]}

机构：

[1] Baptist Cardiac & Vasc Inst, Miami, FL USA

[2] Univ Miami, Miller Sch Med, Dept Surg, Miami, FL 33136 USA

[3] Miami Vet Adm, Miami, FL USA

来源：

JOURNAL OF VASCULAR SURGERY | 2010年 / 52卷 / 01期

关键词：

COLONY-STIMULATING FACTOR; ENDOTHELIAL PROGENITOR CELLS; AUTOLOGOUS TRANSPLANTATION; COMPRESSION; MOBILIZATION; DEVICE;

D O I：

10.1016/j.jvs.2009.12.048

中图分类号：

R61 [外科手术学];

学科分类号：

100210 [外科学];

摘要：

Intermittent programmed compression of the chronically ischemic limb is associated with arteriogenesis. However, progenitor cell elements contributing to this neovascularization are typically diminished in number and function in the elderly dysvascular patient, particularly in the presence of diabetes, renal insufficiency, and cardiac disease. Granulocyte-colony stimulation factor (G-CSF) dramatically boosts the circulating progenitor cell count. G-CSF was administered in 2 patients being treated for ischemic wounds with an intermittent programmed pneumatic compression device (PPCD). Both had comorbidities associated with diminished circulating progenitor cell counts. Remarkable clinical, hemodynamic, and angiographic improvement was observed. Further study of this synergistic strategy is warranted. (J Vasc Surg 2010;52:199-204.)

引用

页码：199 / 204

页数：6

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