Longitudinal and cross-sectional analysis of atrophy in Alzheimer's disease: Cross-validation of BSI, SIENA and SIENAX

被引：94

作者：

Smith, Stephen M.

Rao, Anil

De Stefano, Nicola

Jenkinson, Mark

Schott, Jonathan M.

Matthews, Paul M.

Fox, Nick C.

机构：

[1] Univ Oxford, Ctr Funct MRI Brain, Oxford, England

[2] GlaxoSmithKline Clin Imaging Ctr, Hammersmith, England

[3] Univ Siena, Dept Neurol & Behav Sci, I-53100 Siena, Italy

[4] UCL, Inst Neurol, Dementia Res Ctr, London WC1E 6BT, England

来源：

NEUROIMAGE | 2007年 / 36卷 / 04期

基金：

英国工程与自然科学研究理事会; 英国医学研究理事会;

关键词：

D O I：

10.1016/j.neuroimage.2007.04.035

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Brain volume loss (atrophy) is widely used as a marker of disease progression. Atrophy has been measured with a variety of methods, some estimating atrophy rate from two temporally separated scans, and others estimating atrophy state from a single scan. Three popular tools for measuring brain atrophy are BSI and SIENA (rate) and SIENAX (state). Previous papers have shown BSI and SIENA to have similar accuracy, but no work has carefully compared both methods using the same data set. Here we compare these methods, using data from patients with Alzheimer's disease and age-matched controls. We also compare the SIENA longitudinal measure with atrophy state estimated by SIENAX using just the earliest scan taken from each subject. We show strong correspondence and similar sensitivity to atrophy between all 3 measures. (C) 2007 Elsevier Inc. All rights reserved.

引用

页码：1200 / 1206

页数：7

共 23 条

[1]

[Anonymous], 1998, J COMPUT ASSIST TOMO

[2]

BARTSCH AJ, 2004, 10 ANN M ORG HUM BRA

[3] Manifestations of early brain recovery associated with abstinence from alcoholism [J].