Pelorol from the tropical marine sponge Dactylospongia elegans

被引：52

作者：

Goclik, E

König, GM

Wright, AD

Kaminsky, R

机构：

[1] Tech Univ Braunschweig, Inst Pharmaceut Biol, D-38106 Braunschweig, Germany

[2] Swiss Trop Inst, CH-4002 Basel, Switzerland

来源：

JOURNAL OF NATURAL PRODUCTS | 2000年 / 63卷 / 08期

关键词：

D O I：

10.1021/np990502u

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

From the dichloromethane solubles of the tropical marine sponge Dactylospongia elegans, a new aromatic substituted sesquiterpene, pelorol (1), and the known sesquiterpene, ilimaquinone (2), were isolated. The structures of 1 and 2 were deduced from their spectroscopic data. The biological activities of compounds 1 and 2 were assessed in a variety of bioassays, and both compounds were found to have weak antitrypanosomal and antiplasmodial effects.

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页码：1150 / 1152

页数：3

相关论文

共 13 条

[1] A REVISION OF THE ABSOLUTE STEREOCHEMISTRY OF ILIMAQUINONE [J].

CAPON, RJ ;

MACLEOD, JK .

JOURNAL OF ORGANIC CHEMISTRY, 1987, 52 (22) :5059-5060

[2] QUANTITATIVE ASSESSMENT OF ANTI-MALARIAL ACTIVITY INVITRO BY A SEMIAUTOMATED MICRODILUTION TECHNIQUE [J].

DESJARDINS, RE ;

CANFIELD, CJ ;

HAYNES, JD ;

CHULAY, JD .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1979, 16 (06) :710-718

[3] METABOLITES OF THE PALAUAN SPONGE DACTYLOSPONGIA SP [J].

KUSHLAN, DM ;

FAULKNER, DJ ;

PARKANYI, L ;

CLARDY, J .

TETRAHEDRON, 1989, 45 (11) :3307-3312

[4] SESTERTERPENE LACTONES FROM A SPONGE SPECIES OF THE GENUS DACTYLOSPONGIA [J].

LAL, AR ;

CAMBIE, RC ;

RICKARD, CEF ;

BERGQUIST, PR .

TETRAHEDRON LETTERS, 1994, 35 (16) :2603-2606

[5] DACTYLTRONIC ACIDS FROM THE SPONGE DACTYLOSPONGIA ELEGANS [J].

LOPEZ, MD ;

QUINOA, E ;

RIGUERA, R ;

OMAR, S .

JOURNAL OF NATURAL PRODUCTS, 1994, 57 (07) :992-996

[6] ILIMAQUINONE, A SESQUITERPENOID QUINONE FROM A MARINE SPONGE [J].

LUIBRAND, RT ;

ERDMAN, TR ;

VOLLMER, JJ ;

SCHEUER, PJ ;

FINER, J ;

CLARDY, J .

TETRAHEDRON, 1979, 35 (05) :609-612

[7] Dorisenones, cytotoxic spongian diterpenoids, from the nudibranch Chromodoris obsoleta [J].

Miyamoto, T ;

Sakamoto, K ;

Arao, K ;

Komori, T ;

Higuchi, R ;

Sasaki, T .

TETRAHEDRON, 1996, 52 (24) :8187-8198

[8] 4-aminoquinoline analogs of chloroquine with shortened side chains retain activity against chloroquine-resistant Plasmodium falciparum [J].

Ridley, RG ;

Hofheinz, W ;

Matile, H ;

Jaquet, C ;

Dorn, A ;

Masciadri, R ;

Jolidon, S ;

Richter, WF ;

Guenzi, A ;

Girometta, MA ;

Urwyler, H ;

Huber, W ;

Thaithong, S ;

Peters, W .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1996, 40 (08) :1846-1854

[9] THE STRUCTURES AND STEREOCHEMISTRY OF CYTOTOXIC SESQUITERPENE QUINONES FROM DACTYLOSPONGIA-ELEGANS [J].

RODRIGUEZ, J ;

QUINOA, E ;

RIGUERA, R ;

PETERS, BM ;

ABRELL, LM ;

CREWS, P .

TETRAHEDRON, 1992, 48 (32) :6667-6680

[10] BIOLOGICALLY-ACTIVE SECONDARY METABOLITES OF ENDOPHYTIC PEZICULA SPECIES [J].

SCHULZ, B ;

SUCKER, J ;

AUST, HJ ;

KROHN, K ;

LUDEWIG, K ;

JONES, PG ;

DORING, D .

MYCOLOGICAL RESEARCH, 1995, 99 :1007-1015