Two successive one-pot reactions leading to the expeditious synthesis of (-)-centrolobine

被引：64

作者：

Boulard, L

BouzBouz, S

Cossy, J

Franck, X

Figadère, B

机构：

[1] CNRS, Chim Organ Lab, ESPCI, F-75231 Paris 05, France

[2] Univ Paris Sud, Fac Pharm, CNRS, Lab Pharmacognosie,BioCIS, F-92296 Chatenay Malabry, France

来源：

TETRAHEDRON LETTERS | 2004年 / 45卷 / 35期

关键词：

centrolobine; one-pot reaction; cross-metathesis; allyl-titanation;

D O I：

10.1016/j.tetlet.2004.07.025

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A very short and efficient synthesis of (-)-centrolobine has been achieved by using two successive one-pot reactions. The first sequence involves a cross-metathesis reaction/hydrogenation/lactonization and the second sequence is a Grignard addition/reduction. (C) 2004 Published by Elsevier Ltd.

引用

页码：6603 / 6605

页数：3

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