Scandium-bipyridine-catalyzed enantioselective addition of alcohols and amines to meso-epoxides

被引：130

作者：

Schneider, C ^{[1
]}

Sreekanth, AR ^{[1
]}

Mai, E ^{[1
]}

机构：

[1] Univ Leipzig, Inst Organ Chem, D-04103 Leipzig, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2004年 / 43卷 / 42期

关键词：

asymmetric catalysis; epoxides; N ligands; nucleophilic addition; scandium;

D O I：

10.1002/anie.200460786

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A winning combination of metal and ligand: The catalyst formed in situ from Sc(OTf)3 and bipyridine 1 (10 mol%) mediates the alcoholysis and aminolysis of Mieso-epoxides in high enantioselectivities and furnishes valuable chiral 1,2-diol monoethers 2 and 1,2-amino alcohols 3 as products (PMB = para-methoxybenzyl).

引用

页码：5691 / 5694

页数：4

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