Effect of pregnancy on chronic hepatitis C:: a case-control study

被引：30

作者：

Fontaine, H

Nalpas, B

Carnot, F

Bréchot, C

Pol, S

机构：

[1] Hop Necker Enfants Malad, Unite Hepatol, INSERM, U370, F-75015 Paris, France

[2] Hop Laennec, Serv Anatomopathol, F-75340 Paris, France

来源：

LANCET | 2000年 / 356卷 / 9238期

关键词：

D O I：

10.1016/S0140-6736(00)02823-3

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

There is evidence of deterioration of hepatitis C after pregnancy. To investigate potential histological changes, we compared liver biopsy samples taken before and after delivery from 12 women positive for hepatitis C virus (HCV) and 12 non-pregnant HCV-positive women. Semiquantitative histopathological measurements showed greater deterioration In cases than in controls (necroinflammatory score deterioration 83.3% vs 25.0%; fibrosis score 41.6% vs 8.3%). This case-control study suggests that pregnancy may worsen HVCV-related histopathological injury.

引用

页码：1328 / 1329

页数：2

共 5 条

[1] PATHOGENETIC MECHANISMS OF HEPATOCELLULAR DAMAGE IN CHRONIC HEPATITIS-C VIRUS-INFECTION [J].