Roles of Toxoplasma gondii-derived heat shock protein 70 in host defense against T-gondii infection

被引:15
作者
Ahmed, AK [1 ]
Mun, HS [1 ]
Aosai, F [1 ]
Piao, LX [1 ]
Fang, H [1 ]
Norose, K [1 ]
Yano, A [1 ]
机构
[1] Chiba Univ, Grad Sch Med, Dept Infect & Host Def, Chuo Ku, Chiba 2608670, Japan
关键词
Toxoplasma gondii; Tg.HSP70; immunosuppression;
D O I
10.1111/j.1348-0421.2004.tb03611.x
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
C57BL/6 mice receiving intraperitoneal injection of Toxoplasma gondii-derived heat shock protein 70 (Tg.HSP70) on day 3 post T gondii infection succumbed by day 9 post infection, while vector protein-injected control mice survived more than 6 months. The deteriorating effect of Tg.HSP70 on host immune responses was dose-dependent. By Tg.HSP70 injection, T gondii loads increased in various organs of T gondii-infected mice. Th2 cytokines such as IL-4 and IL-10 were continuously produced from spleen and peritoneal exudate cells of T gondii-infected mice by injection of Tg.HSP70. Furthermore, nitric oxide production from peritoneal macrophages in T gondii-infected mice was reduced by Tg.HSP70.
引用
收藏
页码:911 / 915
页数:5
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