The mild encephalitis-hypothesis - New findings and studies

被引：10

作者：

Bechter, K

机构：

[1] Bezirkskrankenhaus Gunzburg, D-89312 Gunzburg, Germany

[2] Univ Ulm, Ulm, Germany

来源：

PSYCHIATRISCHE PRAXIS | 2004年 / 31卷

关键词：

D O I：

10.1055/s-2004-828428

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Causes and pathogenesis of psychiatric disorders is poorly understood. Infections by viruses or other agents may disturb neurotransmitters and elicit behavioral abnormalities, and induce long lasting immune reactions, referred to as mild encephalitis (ME). New findings (pathology, biochemistry, imaging) in schizophrenia and bipolar psychoses are compatible with ME hypothesis. In Chorea Sydenham and PANDAS syndrome autoimmune ME seems to explain anxiety-compulsive-hyperactivity symptoms. Add-on-therapy with Cox-II-blockers or valacyclovir improved acute schizophrenia, CSF filtration some cases of therapy resistant psychoses.

引用

收藏

页码：S41 / S43

页数：3

相关论文

共 11 条

[1]

Bechter K, 2003, PSYCHIAT PRAX, V30, pS216

[2] Borna disease virus-related therapy-resistant depression improved after cerebrospinal fluid filtration [J].

Bechter, K ;

Herzog, S ;

Schreiner, V ;

Brinkmeier, H ;

Aulkemeyer, P ;

Weber, F ;

Wollinsky, KH ;

Schüttler, R .

JOURNAL OF PSYCHIATRIC RESEARCH, 2000, 34 (06) :393-396

[3]

Bechter K, 1998, MONOGRAPHIEN GESAMTG

[4]

BECHTER K, 2001, ADV BIOL PSYCHIAT, V20, P53

[5] White matter changes in schizophrenia - Evidence for myelin-related dysfunction [J].

Davis, KL ;

Stewart, DG ;

Friedman, JI ;

Buchsbaum, M ;

Harvey, PD ;

Hof, PR ;

Buxbaum, J ;

Haroutunian, V .

ARCHIVES OF GENERAL PSYCHIATRY, 2003, 60 (05) :443-456

[6] Reduction of symptoms by valacyclovir in cytomegalovirus-seropositive individuals with schizophrenia [J].

Dickerson, FB ;

Boronow, JJ ;

Stallings, CR ;

Origoni, AE ;

Yolken, RH .

AMERICAN JOURNAL OF PSYCHIATRY, 2003, 160 (12) :2234-2236

[7] Mimicry and auto antibody-mediated neuronal cell signaling in Sydenham chorea [J].

Kirvan, CA ;

Swedo, SE ;

Heuser, JS ;

Cunningham, MW .

NATURE MEDICINE, 2003, 9 (07) :914-920

[8] Beneficial antipsychotic effects of celecoxib add-on therapy compared to risperidone alone in schizophrenia [J].

Müller, N ;

Riedel, M ;

Scheppach, C ;

Brandstätter, B ;

Sokullu, S ;

Krampe, K ;

Ulmschneider, M ;

Engel, RR ;

Möller, HJ ;

Schwarz, MJ .

AMERICAN JOURNAL OF PSYCHIATRY, 2002, 159 (06) :1029-1034

[9]

Planz Oliver, 2002, P179

[10] Childhood-onset obsessive-compulsive disorder and tic disorders: Case report and literature review [J].

Snider, LA ;

Swedo, SE .

JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY, 2003, 13 :S81-S88