Chemical Gradients and Chemotropism in Yeast

被引：58

作者：

Arkowitz, Robert A. ^{[1
]}

机构：

[1] Univ Nice Sophia Antipolis, CNRS, Inst Canc & Dev Biol, Ctr Biochim,Fac Sci,UMR6543, F-06108 Nice 2, France

来源：

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY | 2009年 / 1卷 / 02期

关键词：

ALPHA-FACTOR PHEROMONE; EXCHANGE FACTOR CDC24; SIGNAL-TRANSDUCTION PATHWAY; PROTEIN-COUPLED RECEPTORS; DUAL LIPID MODIFICATION; SINGLE-POINT MUTATION; SACCHAROMYCES-CEREVISIAE; CELL POLARITY; RESPONSE PATHWAY; A-FACTOR;

D O I：

10.1101/cshperspect.a001958

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Chemical gradients of peptide mating pheromones are necessary for directional growth, which is critical for yeast mating. These gradients are generated by cell-type specific secretion or export and specific degradation in receiving cells. Spatial information is sensed by dedicated seven-transmembrane G-protein coupled receptors and yeast cells are able to detect extremely small differences in ligand concentration across their similar to 5-mu m cell surface. Here, I will discuss our current knowledge of how cells detect and respond to such shallow chemical gradients and in particular what is known about the proteins that are involved in directional growth and the establishment of the polarity axis during yeast mating.

引用

页数：20

共 114 条

[61] THE A-FACTOR TRANSPORTER (STE6 GENE-PRODUCT) AND CELL POLARITY IN THE YEAST SACCHAROMYCES-CEREVISIAE [J].

KUCHLER, K ;

DOHLMAN, HG ;

THORNER, J .

JOURNAL OF CELL BIOLOGY, 1993, 120 (05) :1203-1215

[62] Functional characterization of the Cdc42p binding domain of yeast Ste20p protein kinase [J].

Leberer, E ;

Wu, CL ;

Leeuw, T ;

FourestLieuvin, A ;

Segall, JE ;

Thomas, DY .

EMBO JOURNAL, 1997, 16 (01) :83-97

[63] Aromatic residues at the extracellular ends of transmembrane domains 5 and 6 promote ligand activation of the G protein-coupled α-factor receptor [J].

Lin, JC ;

Parrish, W ;

Eilers, M ;

Smith, SO ;

Konopka, JB .

BIOCHEMISTRY, 2003, 42 (02) :293-301

[64] SPECIFICATION OF SITES FOR POLARIZED GROWTH IN SACCHAROMYCES-CEREVISIAE AND THE INFLUENCE OF EXTERNAL FACTORS ON SITE SELECTION [J].

MADDEN, K ;

SNYDER, M .

MOLECULAR BIOLOGY OF THE CELL, 1992, 3 (09) :1025-1035

[65] Spatial regulation of Fus3 MAP kinase activity through a reaction-diffusion mechanism in yeast pheromone signalling [J].

Maeder, Celine I. ;

Hink, Mark A. ;

Kinkhabwala, Ali ;

Mayr, Reinhard ;

Bastiaens, Philippe I. H. ;

Knop, Michael .

NATURE CELL BIOLOGY, 2007, 9 (11) :1319-U226

[66] Dual lipid modification motifs in Gα and Gγ subunits are required for full activity of the pheromone response pathway in Saccharomyces cerevisiae [J].

Manahan, CL ;

Patnana, M ;

Blumer, KJ ;

Linder, ME .

MOLECULAR BIOLOGY OF THE CELL, 2000, 11 (03) :957-968

[67] DEGRADATION OF A-FACTOR BY A SACCHAROMYCES-CEREVISIAE ALPHA-MATING-TYPE-SPECIFIC ENDOPEPTIDASE - EVIDENCE FOR A ROLE IN RECOVERY OF CELLS FROM G1 ARREST [J].

MARCUS, S ;

XUE, CB ;

NAIDER, F ;

BECKER, JM .

MOLECULAR AND CELLULAR BIOLOGY, 1991, 11 (02) :1030-1039

[68] Pheromone-induced polarization is dependent on the Fus3p MAPK acting through the formin Bni1p [J].

Matheos, D ;

Metodiev, M ;

Muller, E ;

Stone, D ;

Rose, MD .

JOURNAL OF CELL BIOLOGY, 2004, 165 (01) :99-109

[69] Regulation of MAPK function by direct interaction with the mating-specific Gα in yeast [J].

Metodiev, MV ;

Matheos, D ;

Rose, MD ;

Stone, DE .

SCIENCE, 2002, 296 (5572) :1483-1486

[70] Membrane trafficking of heterotrimeric G proteins via the endoplasmic reticulum and golgi [J].

Michaelson, D ;

Ahearn, I ;

Bergo, M ;

Young, S ;

Philips, M .

MOLECULAR BIOLOGY OF THE CELL, 2002, 13 (09) :3294-3302

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