New cyclic peptides from the Indonesian sponge Theonella swinhoei

被引：25

作者：

Roy, MC

Ohtani, II

Ichiba, T

Tanaka, J

Satari, R

Higa, T ^{[1
]}

机构：

[1] Univ Ryukyus, Dept Chem Biol & Marine Sci, Okinawa 9030213, Japan

[2] Okinawa Ind Technol Ctr, Okinawa 9042234, Japan

[3] JL, LIPI, Res & Dev Ctr Oceanol, Jakarta 11048, Indonesia

来源：

TETRAHEDRON | 2000年 / 56卷 / 46期

关键词：

cyclic peptide; depsipeptides; sponge; immunosuppressive activity;

D O I：

10.1016/S0040-4020(00)00762-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Three new cyclic peptides, barangamides B, C, and D and a new depsipeptide, theonellapeptolide IIe as well as known theonellapeptolides Ia, Id, Ie, IId have been isolated from the sponge Theonella swinhoei collected in Baranglompo Island, Indonesia. The structures of barangamides were elucidated by interpretation of NMR data and application of Marfey's method. The structure of theonellapeptolide IIe, a mixture of several conformers showing complex NMR spectra, was determined by MS analysis of a ring-opened product and by chemical reaction. Some of the theonellapeptolides showed mild immunosuppressive activity, while barangamide A was inactive. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：9079 / 9092

页数：14

共 15 条

[1]

DOI M, 1991, J ORG CHEM, V56, P3629, DOI 10.1021/jo00011a033

[2] Marine natural products [J].