Sulfinimine-Mediated Asymmetric Synthesis of 1,3-Disubstituted Tetrahydroisoquinolines:: A Stereoselective Synthesis of cis- and trans-6,8-Dimethoxy-1,3-dimethyl-1,2,3,4-tetrahydroisoquinoline

被引:59
作者
Davis, FA [1 ]
Mohanty, PK [1 ]
Burns, DM [1 ]
Andemichael, YW [1 ]
机构
[1] Temple Univ, Dept Chem, Philadelphia, PA 19122 USA
关键词
D O I
10.1021/ol006654u
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The highly diastereoselective addition of lateral lithiated o-tolunitriles to sulfinimines followed by treatment of the resulting sulfinamide with MeLi, hydrolysis, and reduction represents a concise new methodology for the asymmetric synthesis of 1,3-disubstituted tetrahydroisoquinolines.
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页码:3901 / 3903
页数:3
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